Todo DSpace

Listar por tema "skin fibrosis"

Mostrando ítems 1-7 de 7

    • IL-33/ST2 axis in organ fibrosis 

      Kotsiou O.S., Gourgoulianis K.I., Zarogiannis S.G. (2018)
      Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in immunity and cell homeostasis by ...

    • Immunotherapy of systemic sclerosis 

      Katsiari C.G., Simopoulou T., Alexiou I., Sakkas L.I. (2018)
      Systemic sclerosis (SSc) is a chronic systemic disease characterized by microvasculopathy, immune activation, and extensive collagen deposition. Microvasculopathy and immune activation occur very early in the disease ...

    • A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease 

      Daoussis D., Melissaropoulos K., Sakellaropoulos G., Antonopoulos I., Markatseli T.E., Simopoulou T., Georgiou P., Andonopoulos A.P., Drosos A.A., Sakkas L., Liossis S.-N. (2017)
      Objectives Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients with systemic sclerosis (SSc). We aimed to assess long-term efficacy and safety of RTX in SSc compared to standard treatment. ...

    • The role of B cells in the pathogenesis of systemic sclerosis 

      Sakkas L.I., Bogdanos D.P. (2016)
      Systemic sclerosis (SSc) is characterized by extensive collagen deposition, microvasculopathy and autoantibodies. All three features can be promoted by activation of T cells and B cells. T cells are of Th2 type producing ...

    • Systemic sclerosis: New evidence re-enforces the role of B cells 

      Sakkas L.I., Bogdanos D.P. (2016)
      Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy ...

    • T-cells and B-cells in systemic sclerosis 

      Sakkas, L. I.; Platsoucas, C. D. (2010)
      Systemic sclerosis (SSc) is characterized by activation of fibroblasts with extensive deposition of collagen, by small vessel vasculopathy with fibrointimal proliferation, and activation of the immune system, with hyper-γ- ...

    • Targeting very early systemic sclerosis: a case-based review 

      Melissaropoulos K., Kraniotis P., Bogdanos D., Dimitroulas T., Sakkas L., Daoussis D. (2019)
      It is unknown whether treatment in very early/early systemic sclerosis (SSc) can affect long-term outcomes. A case-based review was conducted (i) to assess the effect of rituximab (RTX) in very early SSc and (ii) to explore ...